Energy & Metabolism

A new $4 million NIH-funded study by UTHealth Houston will investigate the metabolic, genetic and hormonal factors driving weight regain after GLP-1 treatment.

Regeneron's Phase 2 COURAGE trial reports investigational trevogrumab preserved lean mass during semaglutide weight loss without proving functional strength gains.

A 104-week trial found diet drinks and water comparable for weight management within a behavioral program, though high participant attrition limits the findings.

Brief seated movements like soleus push-ups and light resistance exercises can help men over 45 lower post-meal blood sugar and interrupt sedentary time.

A detailed breakdown of recent Acibadem International research evaluating how resistance training, daily movement, and steady cardio impact daily energy use.

A 2026 meta-analysis links higher ultra-processed food intake to metabolic and cardiovascular risks, but experts urge caution regarding socioeconomic variables.

A longitudinal study of Indigenous Bolivian communities reveals that their low dementia prevalence is driven by short survival times, not just diet and activity.

A 2026 meta-analysis of over eight million adults links higher ultra-processed food intake to increased cardiovascular events, cancer and metabolic risks.

A randomized trial shows matched weight loss improves muscle insulin sensitivity across all diets, while a ketogenic plan specifically targets liver fat.

A 12-week Johns Hopkins study found a 10-hour eating window produced modest weight loss similar to a conventional meal schedule for adults with prediabetes.

A Nature Communications cohort study reveals that gut microbiome patterns track systemic inflammation and incident disease risk better than chronological age.

A 2026 DZNE study reveals that adhering to diverse healthy diets like DASH, Nordic, or Mediterranean is consistently linked to slower biological aging.

A UK Biobank analysis reveals that higher volumes of moderate-to-vigorous physical activity substantially lower absolute type 2 diabetes risk in men over 45.

Learn how to interpret common metabolic markers like blood pressure, A1C, fasting glucose and waist size to maintain physical capability and health after 45.

Active men over 45 often need more than the standard minimum to maintain strength. We clarify daily targets, optimal meal timing and safe whole food sources.

Find out why midlife weight gain is rarely caused by a broken metabolism. Learn how daily movement, sleep quality, and functional strength impact energy after 45.

A 2026 Nature Metabolism review suggests fructose acts as a distinct metabolic signal favoring fat storage over energy. We review the evidence for older men.

A review of intermittent fasting trials in adults over 45 shows moderate 10 to 12 hour eating windows improve metabolic health without risking muscle loss.

Recent reviews of 122,007 adults show higher VO2 max is linked to a significantly lower mortality hazard, proving that aerobic fitness remains adaptable after 45.

Daily energy expenditure remains stable until age 60. Learn how subtle changes in daily movement, appetite, and muscle mass actually drive midlife weight gain.

Muscle provides metabolic insurance for men over 45. This guide covers resistance training, protein intake and recovery to preserve your physical capability.

A slow metabolism is rarely the sole cause of midlife weight gain. Learn how daily movement, muscle mass, sleep and medications actually shape energy output.

Apple's redesigned Health app introduces a Longevity tab and Health Age metric. Learn how men over 45 can track metabolic markers and movement data safely.

Recent research shows how GLP-1 weight loss medications affect aging biomarkers and lean mass, highlighting why older men must prioritize strength training.

Losing fat after 45 requires preserving muscle mass. A moderate calorie reduction, resistance training, and adequate protein help maintain physical capability.

We evaluate the clinical evidence behind fasting, cold plunges and metabolism supplements to help men over 45 prioritize safe nutritional and training habits.

Review the evidence on testosterone therapy for energy and body composition. Learn about proper diagnosis, real risks and the impact of lifestyle changes.